Dr. Mohana Rao Patibandla standing at the podium at SIONCON 2025 in Bengaluru, with a large screen displaying his professional profile, qualifications, and fellowships from leading global neurosurgery centers.
Dr. Mohana Rao Patibandla standing at the podium at SIONCON 2025 in Bengaluru, with a large screen displaying his professional profile, qualifications, and fellowships from leading global neurosurgery centers.

By Dr. Mohana Rao Patibandla, Chief Neurosurgeon, Dr. Rao’s Hospital, Guntur

Introduction: The Future of Neurosurgery Is Here

Brain and spine surgeries are among the most delicate and high-risk procedures in all of medicine. Surgeons work within millimeters of the structures that control movement, speech, vision, memory, and breathing. Even a minor surgical disruption can lead to paralysis, speech loss, or permanent disability.

For decades, neurosurgeons relied solely on their anatomical knowledge, experience, and the microscope to navigate these high-risk regions. But in the last few years, a revolutionary tool has transformed neurosurgical safety worldwide:
Intraoperative Neuromonitoring (IONM).

In November 2025, at SIONCON 2025, held at the prestigious NIMHANS Convention Centre, Bengaluru, I had the honor of presenting one of India’s most comprehensive IONM datasets—a 1008-case analysis covering diverse brain and spine surgeries performed over 5 years at Dr. Rao’s Hospital, Guntur.

The presentation demonstrated how real-time neuromonitoring can significantly reduce neurological complications and improve outcomes, even in the most complex neurosurgical cases.

This blog explains the entire study in a clear, patient-friendly way, detailing how IONM protects patients, helps surgeons make safer decisions, and is shaping the future of neurosurgery in India.

Chapter 1: What Exactly Is Intraoperative Neuromonitoring (IONM)?

Imagine having a real-time safety system during surgery that continuously checks how your brain, spine, and nerves are functioning—even while under anesthesia.
That is the power of IONM.

IONM monitors:

  • Motor function

  • Sensory pathways

  • Cranial nerve function

  • Language and speech centers (in awake surgeries)

  • Brainstem responses

  • Electrical activity of nerves and muscles

If anything harmful begins to happen—such as nerve stretching or decreased blood supply—the system alerts the surgical team immediately.

It is like having a “nerve safety alarm” during surgery.

Why IONM Is Critical in Modern Neurosurgery

Without IONM, nerve injury might be detected only after surgery, when it is too late to reverse the damage.
With IONM, however, risks are identified immediately, allowing the surgeon to respond and prevent permanent injury.

This simple concept can save movement, speech, vision, swallowing ability, and quality of life.

Chapter 2: Why This 1008-Case Study Is a Landmark for India

IONM is still growing in India.
Most hospitals use it only for select cases.
Very few centers have standardized, protocol-driven multimodal IONM across multiple years of surgical work.

At Dr. Rao’s Hospital, we took a different approach:

We used IONM in over 1000 surgeries across:

  • Brain tumors (including eloquent cortex tumors)

  • Skull base and brainstem lesions

  • Spine surgeries

  • Pediatric neurosurgery

  • Epilepsy surgery

  • Awake craniotomy

  • Vascular and endovascular neurosurgery

We also implemented a strict, step-by-step protocol to ensure quality, accuracy, and meaningful intervention whenever signals changed.

This dataset is among the largest single-center IONM studies from India, and the presentation at SIONCON 2025 highlighted the clinical impact of every modality.

Chapter 3: Study Results Explained Simply

Below is a simplified explanation of the key results we presented at SIONCON:

1. Diagnostic Accuracy: IONM Predicts Danger Early

Sensitivity: 85.7%

This means IONM correctly detected 85.7% of cases where something was going wrong.

Specificity: 98.8%

This means IONM rarely gave false alarms.

These numbers show the system is both reliable and precise. Out of 1008 surgeries:

  • True Positives (TP): 186

  • True Negatives (TN): 781

  • False Positives (FP): 10

  • False Negatives (FN): 31

IONM accurately predicted neurological outcomes in 967 out of 1008 cases.

2. Neurological Recovery & Complication Reduction

Key highlights:

  • 78.5% prevention rate for neurological deficits

  • 94% of temporary deficits recovered within 3 months

  • Only 2.1% permanent deficits, mostly in complex eloquent tumors

  • Permanent signal loss: 0.7%

  • Functional independence (KPS ≥80): 91.6% at 3 months

These outcomes match or exceed global neurosurgical benchmarks—reinforcing that India can deliver world-class results.

Chapter 4: Pathology-Wise Outcomes

Eloquent Area Brain Tumors (Movement/Speech Regions)

  • Very high risk surgeries

  • Permanent deficits only 2.1%

  • Safe maximal tumor removal possible

Epilepsy Surgery

  • 88.4% deficit prevention

  • Excellent long-term functional outcomes

Spine Surgery

  • 83.1% deficit prevention rate

  • EMG and MEP monitoring prevented nerve-root injury

Brainstem and Posterior Fossa Surgeries

  • Extremely high-risk surgeries

  • 76.9% neurological protection

Vascular Lesions (AVMs, Aneurysms)

  • 74.2% prevention rate

This shows IONM’s benefit across all neurosurgical domains.

Chapter 5: Pediatric Neurosurgery—Why Children Benefit More

Children’s brains have an amazing ability to recover—known as neuroplasticity.

With IONM:

  • Surgeons can safely operate on epilepsy-causing lesions

  • Brain tumors near critical regions can be removed precisely

  • Early intervention improves long-term development

The study showed better recovery rates in children than adults.

Chapter 6: Awake Brain Surgery—Speaking or Moving During Surgery

Awake craniotomy is a specialized surgery where:

  • The patient is awake during part of the operation

  • They speak, count, or move their hands/legs

  • The surgeon maps critical functions using DES/DCS stimulation

  • Tumors near speech/motor regions can be removed more safely

Results from 227 Awake Surgeries:

  • 11% transient problems

  • 0% long-term complications

  • Best outcomes achieved with DES/DCS mapping

This is among the largest awake craniotomy series in the region.

Chapter 7: What Happens When the Signal Drops?

A small percentage of patients show irreversible signal loss during surgery.

At our hospital, we follow a 5-step Signal Loss Protocol:

  1. Recheck connections, anesthesia, temperature

  2. Increase blood pressure (MAP >90 mmHg)

  3. Reduce traction, decompression

  4. Re-monitor for 3–5 minutes

  5. If no recovery → Staged closure

Results:

  • 26 staged closures (2.6%)

  • Planned re-interventions

  • 73% regained neurological function

This approach prevents permanent disability.

Chapter 8: Why Structured Protocols Matter

IONM isn’t just equipment—it’s a full system.

We use:

  • Standard stimulation thresholds

  • Validated alert criteria

  • Multimodal monitoring (MEP, SSEP, EMG, DES, BAER)

  • Collaboration with anesthesia

  • Checklists for every signal change

Our structured approach ensures maximum safety.

Chapter 9: Why India Needs Wider IONM Adoption

In India, many surgeries are still performed without IONM due to cost, lack of trained personnel, or limited awareness.

But the consequences of nerve injury—lifelong disability—are far more expensive.

Our study clearly shows:

  • Fewer complications

  • Better functional outcomes

  • Safer maximal resection

  • Higher quality of life

  • Lower long-term costs for families

IONM must become a standard of care, not a luxury.

Chapter 10: About Dr. Rao’s Hospital, Guntur

Dr. Rao’s Hospital is one of India’s leading centers for:

  • Advanced neurosurgery

  • Pediatric neurosurgery

  • Epilepsy surgery

  • Endoscopic skull base surgery

  • Minimally invasive spine surgery

  • Neuro-oncology

  • Endovascular neurosurgery

  • Full-scale IONM-supported neurosurgery

We strongly believe in precision, safety, and functional preservation.

With international training from the USA (UVA, OSU, NCH, Colorado), and over 70 publications and 50+ invited lectures,
Dr. Mohana Rao is widely known as:

  • The best neurosurgeon in Guntur

  • The best neurologist in Guntur

  • The best spine surgeon in Guntur

Conclusion: A New Era of Safe Neurosurgery in India

The 1008-case IONM study presented at SIONCON 2025 is more than just academic research—it is proof that:

  • Indian hospitals can match global neurosurgical standards

  • Structured IONM can prevent disability

  • Safe maximal resection is achievable

  • Pediatric and awake surgeries benefit enormously

  • Neuromonitoring must become routine across centers

At Dr. Rao’s Hospital, we continue to advance neurosurgical care with innovation, precision, and compassion.

Contact Us

📞 90100 56444
🌐 https://drraoshospitals.com
📧 info@drraoshospitals.com
📍 Guntur, Andhra Pradesh

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📍 Dr. Rao’s Hospital
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Opp. Sravani Hospital, Guntur, Andhra Pradesh

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